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METHACRYLATE-BASED COATINGS
1] Description:
Methacrylate-based coating materials with a variety of functional properties.
| Functionality |
Trade name |
| Anionic polymer of methacrylic acid and methacrylates with
a -COOH group |
Eudragit® L 100-55 - powder, spray
dried L 30 D-55 which can be reconstituted for targeted delivery in the
duodenum
Eudragit® L 30 D-55 - aqueous dispersion, pH
dependent polymer soluble above pH 5.5 for targeted delivery in the
duodenum
Eudragit® L 100 - powder, pH dependent polymer
soluble above pH 6.0 for targeted delivery in the jejunum
Eudragit® S 100 - powder, pH dependent polymer
soluble above pH 7.0 for targeted delivery in the ileum.
Eudragit® FS 30 D - aqueous dispersion, pH
dependent polymer soluble above pH 7.0, requires no plasticizer
|
| Cationic polymer with a dimethylaminoethyl ammonium group |
Eudragit E 100 - granules, pH dependent,
soluble in gastric fluid up to 5.0, swellable and permeable above pH
5.0.
Eudragit® E PO - powder form of E-100
|
| Copolymers of acrylate and methacrylates with quarternary
ammonium group. |
Insoluble, High Permeability
Eudragit® RL 30D - aqueous dispersion, pH
independent polymer for sustained release formulations
Eudragit® RL PO - powder, pH independent
polymer for matrix formulations
Eudragit® RL 100 - granules, pH independent
Insoluble, Low Permeability
Eudragit® RS 30D - aqueous dispersion, pH
independent polymer for sustained release formulations
Eudragit® RS PO - powder, pH independent
polymer for matrix formulations
Eudragit® RS 100 - granules, pH independent
|
| Copolymers of acrylate and methacrylates with quarternary
ammonium group in combination with sodium carboxymethylcellulose |
Eudragit RD 100 - powder, pH independent
for fast disintegrating films |
2) Applications:
| Enteric Coatings |
Eudragit® L 100-55
or L 30 D-55 - delivery to the duodenum (pH > 5.0). Exact pH
controlled drug release can be adjusted by a combination of polymers and
coating thickness.
Eudragit® L 100 - delivery to the jejunum (pH >
6.0).
Eudragit® S 100 - delivery to the intestine (pH
6.0 to 7.5), site specific drug delivery can be achieved by combining
with Eudragit® L types.
Eudragit® FS 30 D - delivery to the colon (pH
>7.0).
Acryl-eze® --one step dry enteric coating
system, soluble at pH 5.5 |
| Sustained Release Coatings |
Eudragit® RL and
RS - release profile determined by the ratio of RL to RS polymers, and
the film thickness applied. |
| Taste Masking |
Eudragit® RD
100, pH independent, fast disintegrating film
Eudragit® E 100 and EPO,
pH dependent cationic polymer, soluble in gastric fluid up to pH 5.0,
swellable and permeable above pH 5.0 |
| Rapidly disintegrating Films |
Eudragit® RD
100 |
3] Suppliers:
Need a supplier?
Submit a request in Excipients
Express!!!
4) References Eudragit
technical bulletin, Rohm America
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