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Lactose Anhydrous

1] Description:  White or almost white,  powder or free flowing powder.

Note: Browning of the product occurs when combined with amines (Kosky, K.T. et. al., Hammouda, Y. and Salakawy, S.A., and Severine, T. and Loidl, A.).
  

2] Physical Characteristics:

Water Content: NMT 1.0%

LOD: NMT 0.5%

 

Typical Properties

Pharmatose® DCL 21*

Sheffield

DT

Sheffield

60M

Typical Bulk Density (g/cc)

0.63 -- --
Particle Size Specification NMT 20% < 45 microns

40 - 65% < 150 microns

NLT 80% < 250 microns

10-20% = 60 mesh

15-30% = 80 mesh

7-15% = 100 mesh

6-20% = 200 mesh

20-30% thru 200 mesh

0-5% = 60 mesh

10-30% = 80 mesh

7-20% = 100 mesh

10-25% = 200mesh

10-40% thru 200 mesh

 

* Measured by mechanical sieve shaker


3] Applications: 

Wet granulation filler/binder
Direct compression filler/binder

4] Suppliers:

Need a supplier? Submit in Excipients Express!!!

5] References:

Kosky, K.T., Duvall, R.N., Troup, A.E., Pyles, J.W. (1965) Factors involved in the 

          Browning of Spray-dried Lactose, J Pharm Sci, 54:4, 549-554.
  

Hammouda, Y. and Salakawy, S.A., (1971) Non-enzymatic Browning in 

          Solid-dosage Forms: Lactose-induced Discoloration of Neomycin Tablets, 

          Pharmazie, 26:10, 636-640.
  

Severine, T. and Loidl, A. (1976) Formation of Pyridone Derivates from Maltose 

          and Lactose. XII. Investigations on the Maillard-reaction, Z Lebensm Unters 

          Forsch, 161:2, 119-124.

 
Pharmatoseâ DCL 21, Lactose Anhydrous NF – Product Bulletin rev. 4/99, CHR Hansen

 

Sheffield™ Brand Anhydrous Lactose NF, Product Information, 2002

 

Pformulate/lactoanhyd/09/14/2002 updated 08/15/2004