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XANTHAN GUM

1] Description:  Exocellular heteropolysaccharide produced by fermentation. Exhibits pseudoplastic behavior in solution (i.e. high viscosity at rest, viscosity decreases with increasing shear rates, and instantly returns as shear is reduced or removed). Higher degree of pseudoplasticity than other commercial hydrocolloids.

 Viscosity is maintained over a wide pH range (pH 2 to 12).  Compatible with most common acids, and most basic compounds.

 pH increases in the presence of soluble multivalent cations, which can cause cross-linking to an insoluble gel.

 Viscosity increases in the presence of a salt, including divalent metal salts such as calcium and magnesium.

2] Physical Characteristics:

Typical Properties

Mesh Size

Viscosity (mPa sec)

Xantural® 180

80

1200-1600

Xantural® 75

200

1200-1600

Xantural® 11K

14

1200-1600

 

3] Applications: 

 

Liquid  Formulations

Standard grade, Xantural 180, emulsion stabilizer, viscosifier, suspending agent
Gelling agent: Use level 0.05 to 0.50%.
Controlled release tablets  Xantural 75
Dry blends  Xantural 75
 XTL 75: rapid hydration in reconstitutedproducts 
Dispersant Use Xantural 11K: easy to disperse grade suitable for low energy mixing conditions or for products that are considered a "delicate" emulsion

 

4] Suppliers:

CPKelco     Xantural® Grades 180, 75, 11k, EP, JPE, USP/NF

 

Need a supplier? Submit in Excipients Express!!!

 

5] References:

Xantural Family of Xanthan Gum Products for Pharmaceutical Application rev.10/99, Kelco Biopolymers

 

 

Pformulate/01/25/2004