Oils such as soybean oil and Miglyol 812 (neutral oil, triglycerides of medium chain fatty acids)

	Polyethylene Glycols: especially PEG 400 -600
	Other solvents: Any other solvent which doesn't degrade or solubilize the gelatin shell, i.e., dimethyl isosorbide, surfactants, diethylene glycol monoethly ether
	Optional Ingredients: Water or alcohol: up to 10% w/w, if needed for solubility Glycerin: 1 to 4% w/w to retard the migration of the glycerin out of the shell into the fill Polyvinylpyrrolidone: Up to 10% w/w used in combination with PEG, can increase drug solubility, and also improve stability by inhibiting drug recrystallization

 

	Suspensions can accommondate about 30% solids before viscosity and filling become a problem
	Suspensions can be heated up to 35ºC to decrease viscosity during the filling process
	Suspended solids must be smaller than 80 mesh -- mill or homogenize before filling to prevent needles from clogging during filling.
	Carriers Oily mixtures: Traditional: Soybean Oil with beeswax (4-10% w/w) and lecithin (2-4% w/w). The lecithin improves material flow, and imparts some lubrication during filling. Add enough beeswax to get a good suspension, but avoid creating a non-dispersible plug.  Gelified Oil (e.g. Geloil® SC), a ready to use system composed of soybean oil, a suspending agent, and a wetting agent. Simplifies the manufacturing process, and avoids batch to batch and supplier to supplier variability.   Polyethylene glycol PEG 800 -1000 for semi-solid fills PEG 10,000 -100,000for solid fills Or mixtures of the above. Heat up to 35ºC to make fluid enough for filling. Glycerides Glycerides of long chain fatty acids (e.g. Gelucire® 33/01). Hydrophobic with surfactant properties. Optional Ingredients: Surfactant: sorbitan derivatives such as polysorbate 80 or lecithin. For hydrophobic drugs dissolved or dispersed in an oily matrix, a surfactant of HLB 10 will increase the dispersibility of the product in aqueous fluids and also may improve bioavailability.