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2004 Pformulate.
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Sodium Starch Glycolate
1] Description: Sodium salt of carboxymethyl ether of
starch. White to off-white, tasteless, odorless, relatively free flowing
powder. Practically insoluble in organic solvents.
Absorbs water rapidly, resulting in swelling which leads to rapid
disintegration of tablets and granules.
2] Physical Characteristics:
|
VivastarÒ Type |
Viscosity
(2% solution) mPa s |
|
*P |
Non-viscous |
|
P 0100 |
< 800 |
|
P 1000 |
< 2000 |
|
P 1500 |
> 1500 |
|
P 3500 |
>
2000
<
5000 |
|
P 5000 |
> 5000 |
* P refers potato
starch origin. Also available from corn, wheat, and rice origins.
3] Applications:
| Disintegrant |
dissolution aid for tablets, capsules and pellets
Recommended concentration: 1.0 – 4.0%. May need
to use up to 6.0% In wet granulation formulations, normally effective
intragranularly. However, may be more effective if added 50% intragranularly,
and 50% extra-granularly (in the final dry mixture).
Explotab
and VivastarP, for direct compression
Explotab
CLV, for use intragranularly
Explotab
Low pH, for use with actives susceptible to high pH
Explotab
V17, provides enhanced swelling
Vivastar
(PFS), Solvent Free
|
| Suspending agent |
|
|
|
| Gelling agent |
VivastarÒ comes in a
wide variety of types which can be used with water to produce translucent
suspensions or clear gels over a wide viscosity range. |
4] Suppliers:
| JRS |
Explotab andVivastarÒP
, NF, JPE, Type A Ph.Eur., BP |
Need a supplier?
Submit in Excipients Express!!!
5] References:
TabloÒ
, Technical Brochure, Blanver
VivastarÒ
, Technical Brochure, J. Rettenmaier and Sohne GMBH and Co.
ExplotabÒ,
http://www.jrspharma.com/tabingred_disintegrants.php
Pformulate/11/28/2004
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