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2004 Pformulate.
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Microcrystalline Cellulose
1] Description: Purified, partially depolymerized alpha
cellulose derived from purified specialty grades of wood pulp. A white,
odorless, tasteless, free flowing powder. Insoluble in water, dilute acids,
and most organic solvents. Practically insoluble in sodium hydroxide. There
are various grades which differ in bulk density, particle size and moisture
content.
2] Physical Characteristics:
|
Product
Small Particle Size*
|
Bulk Density (g/cc)
|
Loss on drying (%)
|
Typical Average Particle
size (microns)
|
|
VivapurÒ
99
|
0.2
|
< 5
|
12
|
|
AvicelÒ
PH 105
|
0.25
|
3
|
20
|
|
VivapurÒ
105
|
0.23
|
< 5
|
25
|
* Sorted by Particle Size
|
Product
Original*
|
Bulk Density (g/cc)
|
Loss on drying (%)
|
Typical Average Particle size
(microns)
|
|
AvicelÒ
PH 101
|
0.28
|
4
|
50
|
|
TabuloseÒ
101
|
0.2-0.4
|
< 5
|
50
|
|
VivapurÒ
101
|
0.29
|
< 5
|
50
|
|
AvicelÒ
PH 102
|
0.30
|
4
|
90
|
|
VivapurÒ
102
|
0.31
|
< 5
|
90
|
|
TabuloseÒ
102
|
0.2-0.4
|
< 5
|
100
|
* Sorted by Particle
Size
|
Product
Large Particle Size*
|
Bulk Density (g/cc)
|
Loss on drying (%)
|
Typical Average Particle
size (microns)
|
|
VivapurÒ
12
|
0.33
|
< 5
|
160
|
|
AvicelÒ
PH 200
|
0.32
|
4
|
180
|
|
VivapurÒ
200
|
0.34
|
< 5
|
190
|
|
TabuloseÒ
250
|
0.2-0.4
|
< 5
|
230
|
|
TabuloseÒ
500
|
0.2-0.4
|
< 5
|
270
|
* Sorted by Particle
Size
|
Product
Low Moisture*
|
Bulk Density (g/cc)
|
Loss on drying (%)
|
Typical Average Particle size (microns)
|
|
AvicelÒ
PH 113
|
0.30
|
1
|
50
|
|
AvicelÒ
PH 112
|
0.30
|
1
|
90
|
|
TabuloseÒ
112
|
0.2-0.4
|
< 1.5
|
100
|
|
AvicelÒ
PH 103
|
0.28
|
2
|
50
|
|
TabuloseÒ
103
|
0.2-0.4
|
< 3
|
50
|
|
VivapurÒ
103
|
0.32
|
< 3
|
50
|
|
VivapurÒ
112
|
0.35
|
< 3
|
90
|
* Sorted by Moisture
Content
|
Product
High Density*
|
Bulk Density (g/cc)
|
Loss on drying (%)
|
Typical Average Particle size (microns)
|
|
AvicelÒ PH 301
|
0.38
|
4
|
50
|
|
VivapurÒ 301
|
0.38
|
< 5
|
50
|
|
TabuloseÒ 301
|
0.3-0.5
|
< 5
|
50
|
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AvicelÒ PH 302
|
0.39
|
4
|
90
|
|
VivapurÒ 302
|
0.40
|
< 5
|
90
|
|
TabuloseÒ 302
|
0.3-0.5
|
< 5
|
100
|
* Sorted by Bulk Density
and Particle Size
3]
Applications:
Direct
compression Use grade 12, 102, 200, 302, or 112
Grade 12
has a larger particle size that grade 102, and better flow properties
Grade 200
has the largest particle size and better flow
Grade 302
has the same particle size as 102 but higher bulk density and better flow
Grade 112
has a lower moisture content than grade 102
Wet
granulation Use grade 101 or 301
Grade 301
has the same particle size as 101, but higher bulk density and better flow
Slugging
or roller
Compaction
Use grade 102, 302, or 112
Encapsulation
Use grade 102, 302, or 112
Spheronization
Use grade 101, or 301
4] Suppliers:
| JRS |
VivapurÒ
, microcrystalline cellulose, DAB, JP NF, Ph.Eur
Grades:
Small
Particle Size: 99, 105
Original:
101, 102
Low
Moisture: 103, 112
Large
Particle Size: 12, 200
High
Density: 301, 302 |
Need a supplier?
Submit requests in Excipients
Express!!!
5] References:
Quality Excipients
Technical Brochure, Blanver Farmoquimica LTDA.
AvicelÒ
, Electronic Matter, FMC Corporation
VivapurÒ
, Technical Brochure, J. Rettenmaier and Soehne GMBH+CO
Pformulate/05/15/2000
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