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2004 Pformulate.
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Mannitol
1] Description:
Mannitol is a naturally occurring sugar
alcohol. 50% as sweet as sucrose. Non-cariogenic and sugar free. Cooling taste. Non-hygroscopic and chemically
inert. Does not undergo the Maillard reaction, and therefore does not discolor
in the presence of free amines.
Available as powder, and granular.
Mannitol Granular is free flowing.
2] Physical Characteristics:
|
Typical Properties |
Powder |
Mannogem® Granular |
Mannogem® Granular 2080 |
Mannogem® Granular 3215 |
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Particle Size Specification (Microns)
|
150 |
170-1190 |
150-590 |
150 - 590 and 23% < 74 |
3] Applications:
| Wet
granulation |
Mannitol
powder
Mannogem® and Pearlitol®
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| Direct
compression |
Mannitol
granular |
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Mannogem®
granular is a coarse grade of mannitol. Granular 2080 has a tightly controlled
size distribution with less coarse particles compared to the granular grade
for less segregation issues. Granular 3215 similar to granular 2080, but with
more fine particles to help bind extremely fine drug substances.
Partech M®: good for tableting poorly compressible actives.
Facilitates fast disintegration of tablets with high hardness.
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| Chewable
Tablets |
Favorable
mouth-feel |
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| Suspensions |
Mannitol
powder |
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| Injectibles |
Getec
Mannitol Pyrogen Free |
4] Suppliers:
Need a supplier?
Submit in Excipients
Express!!!
5] References:
Mannogem® Mannitol Technical Bulletin #112, SPI Pharma Group
Pformulate/01/02/03
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