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Glyceryl Behenate

1] Description:  Off white powder. Tasteless, non-reactive with other formulation ingredients.  

 

2] Physical Characteristics:

Typical Properties

Compritol®  888 ATO

Water Content (%)

NMT  0.5%

 

 

Particle Size Distribution 

 

through US 250 mesh

 85%
 

3] Applications: 

Lubricant

Tablets and capsules. Decreases ejection force and improves compressibility. Not sensitive to overblending. Does not interfere with tablet disintegration or drug release rate.

Pellets

Can be incorporated into pellets via extrusion/spheronization. Microcrystalline cellulose pellets containing Compritol®  888 ATO, can be compressed into tablets.

 

4] Suppliers:

Need a supplier? Submit in Excipients Express!!!

 

5] References:

Compritol®  888 ATO, Advanced Tablet and Capsule Lubricants, Product Brochure, Gattefosse

Shah, N.H., Stiel, D., Weiss M., Infeld, M.H., and Malick, A.W. (1986). Evaluation of two new tablet lubricants - sodium stearyl fumarate and glyceryl behenate - Measurement of physical parameters (compaction, ejection and residual forces) in the tabletting process and the effect on the dissolution rate, Drug Dev and Ind Pharm, 12, 8-9.

 

Pformulate 04/20/2000