2004, 2005 Pformulate.
PLASTICIZERS FOR COATINGS
Plasticizers come in a wide variety of solubility and functional properties.
In general their use is to reduce the glass transition temperature of a
polymer making it more elastic, and deformable (flexible).
||A Blend of plasticizers used in
acrylic emulsion coatings, composed of:
Glyceryl Monostearate, Polysorbate 80, Triethylcitrate,
Methyl Parabens and Propyl Parabens
Contains a slip agent which greatly reduces the
tackiness of acrylic emulsion coatings.
|| Triethyl citrate (TEC) most water
soluble (5.5 g/100ml)
Acetyltriethyl Citrate (ATEC) slightly soluble in
water (0.72 g/100ml)
Acetyltri-n-butyl Citrate (ATBC) water insoluble
||Plas II is compatible with most
acrylic emulsion coating formulations.
Used at a ratio of approximately 15 acrylic emulsion
solids to one Plas II solid.
|Citrate Esters: used as plasticizers
for aqueous based coatings. Both hydrophilic and lipophilic esters are
available, which can be used to vary film properties and release rates.
Very effective in retarding drug release in acid media, making them a
good choice for enteric coatings. Film permeability and drug release
rate is highest with low molecular weight citrates (e.g. TEC and ATEC)
used at high concentration. Higher molecular weight citrates (ATBC) used
at low concentrations provide lower permeability and slow drug release.
Used at a level of 10 to 40% by weight of dry solids.
Effective in both aqueous and solvent based coating
Need a supplier? Submit in Excipients
Plas II Technical Data SHeet, Emerson Resources, Inc.
Dibutyl Sebacate, NF, rev. 9/98, Morflex, Inc.
Citrate Plasticizers for Pharmaceutical Coatings Bulletin
102, Morflex, Inc.