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CROSPOVIDONE

1] Description:  White, free flowing, compressible powder. A synthetic homopolymer of cross-linked N-vinyl-2-pyrrolidone.

Solubility: Completely insoluble in water, acids, alkalis, and all organic solvents. Hygroscopic. Swells rapidly in water. Rapidly disperses in water, but does not gel even after prolonged exposure.

Chemical Activity: Chemically inert. Has a high adsorptive capacity, forms reversible physical complexes with many molecules without the formation of covalent chemical bonds.

2] Physical Characteristics:

pH (10% slurry): 5.0 – 8.0

Moisture (Karl-Fisher): £ 5.0%

Product

Typical Average Particle size (microns)

Tap Density (g/cc)

Bulk Density (g/cc)

Polyplasdone XL

100

0.3

0.2

Polyplasdone XL-10

30

0.5

0.3

Polyplasdone INF-10

11

0.5

0.4

 

3] Applications:

Wet granulation

Disintegrant/super-disintegrant

Dry granulation

Greatest rate of swelling compared to other disintegrants

Direct compression

Greater surface area to volume ratio than other disintegrants typically used at a level of 1 to 3%

Dissolution aid for tablets, capsules and pellets

 

4] Suppliers:

Need a supplier? Submit in Excipients Express!!!

 

5] References:

Polyplasdone, Crospovidone NF, Technical Profile, ISP

Pformulate/03/08/2000