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2004, 2005 Pformulate.
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CELLULOSE-BASED COATINGS
1] Description:
Cellulose-based coating materials are available with a variety of functional
properties.
| Polymer |
Trade Name |
| Cellulose Acetate Phthalate
(CAP) |
Aquacoat CPD® Aqueous Dispersion (30% solids) |
| C-A-P NF Eastman |
| Hydroxypropylmethylcellulose (HPMC) |
Sepifilm™ LP |
| Hydroxypropylcellulose HPC) |
Klucel® |
| Hydroxypropylethylcellulose (HPEC) |
|
| Ethylcellulose |
Aquacoat® ECD, Aqueous Dispersion, (30% solids) |
| Aqualon® |
| Surelease®, Aqueous Dispersion, (25%
solids) |
| Methylcellulose |
Metolose® SM-4, extremely low viscosity
methylcellulose for film coating |
| Microcrystalline Cellulose and Carrageenan |
LustreClear™, All-in-one coating system |
2] Applications:
| Enteric Coatings |
Aquacoat® CPD Cellulose Acetate phthalate
aqueous dispersion.
C-A-P NF Eastman is used in solvent based coatings
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| Polymer Extenders |
Klucel® EF and LF enhance the utility of
HPMC. Eliminates bridging, improve adherence to problem tablet
substrates, reduce the incidence on film cracking on the tablet edge. |
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| Immediate Release Coatings |
moisture barrier/sealant: use Aquacoat® ECD,
Opadry® AMB, Sepifilm™ LP, Surelease®
taste masking: use Aquacoat® ECD, LustreClear™,
Metolose® SM-4, Surelease®
LustreClear™ is used as an
aqueous clear film coating. It allows for short hydration time prior to
coating and fast drying. Its smooth satin-like finish eliminates edge
wear and logo bridging.
Sepifilm™ LP is a ready to use, gastrosoluble
composition for the film-coating of moisture sensitive solid particles.
Plasticized with stearic acid. Shows significantly lower moisture
permeability compared to PVA and other HPMC based coating formulations. |
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| Sustained Release Coatings |
Ethylcellulose-based
coatings:
Aquacoat® ECD
Aqualon®
Surelease®,
a complete, optimally plasticized system for modified release. |
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| Subcoat |
Klucel® EF is a highly flexible film
former, and is an excellent subcoat for tablets that are difficult to
coat. |
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| Pellet Coating |
Metolose® SM-4, low viscosity (4mPas),
less tacky, and therefore better than HPMC for fine pellet coating |
3] Suppliers:
Need a supplier? Submit in Excipients
Express!!!
4] References:
FMC's Excipients for Pharmaceutical Tablets, Capsules and
Suspensions
Hercules Technical Bulletin VC-556C, The Use of Klucel®
Pharm Hydroxypropylcellulose to Increase the Utility of Hydroxypropyl
Methylcellulose in Aqueous Film Coating.
Hercules Technical Bulletin VC-598A, Klucel®
EF Pharm Hydroxypropylcellulose Use in Plasticizer-Free Aqueous Film Coating.
Metolose® SM-4, Technical Information No. M-1 September,
1999, ShinEtsu
Sepifilm™ LP, Seppic Technical Bulletin 2001
Pformulate 9/26/2000,
4/16/2002, 07/17/2005
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