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2000 Pformulate.
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L-HPC
(Low-substituted hydroxypropyl cellulose)
1] Description: A
low-substituted hydroxypropyl ether of cellulose.
Solubility: Completely insoluble in water, and alcohol. Dissolves in
10% NaOh solution to give a viscous solution. Swells rapidly in water.
2] Physical Characteristics:
pH (slurry): 5.0 –7.5
Loss on Drying: £
5.0%
|
Product |
Average Particle size (microns) |
Hydroxypropyl content |
Bulk Density (g/cc) |
|
LH-11
|
50
|
medium
|
0.34 |
|
LH-21
|
40
|
medium
|
0.40 |
LH-31
|
25
|
medium
|
0.30 |
| LH-22
|
40
|
low
|
0.37 |
| LH-32
|
25
|
low
|
0.21 |
| LH-20
|
40
|
high
|
0.36 |
| LH-30
|
25
|
high
|
0.25 |
3] Applications:
Disintegrant
|
Wet granulated and directly
compressed tablets.
Types with a larger average
particle size and higher hydroxypropyl content show higher degree
of swelling. |
| Binder |
Direct compression.
LH-22 provides greater binding while retaining disintegration
properties. Binder levels are in the 25% range.
LH-11 is useful to prevent capping. |
4] Suppliers:
Need a supplier?
Submit in Excipients
Express!!!
5] References:
L-HPC, NF,
Disintegrant-Binder Product Literature, Shin-Etsu Chemical Co., Ltd., rev.
2000.3
Pformulate/06/26/2002
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